Radiosynoviorthesis (RSO)

Radiosynoviorthesis: A new therapeutic and diagnostic tool for canine joint inflammation.
Donecker JM, Stevenson NR. In: Fox SM (editor). Multimodal Management of Canine Osteoarthritis (2nd Edition) CRC Press. 2017:75-80.

Radiosynoviorthesis using Sn-117m colloid to treat canine elbow osteoarthritis demonstrates efficacy and safety.
Doerr CA, et al. Accepted for poster presentation at the 32nd Annual Congress of the European Association of Nuclear Medicine, October 11-16, 2016, Barcelona, Spain.

Monte Carlo simulation of the dose from radiosynoviorthesis using Sn-117m, Er-169, and Re-186 including stochastic macrophage motion.
Gupta AC, et al. Oral presentation at the American Association of Physicists in Medicine 2018 Annual Meeting, July 29-August 2, 2018, in Nashville, TN.

Experience using homogeneous Sn-117m colloid for RSO.
Doerr CA. Invited lecture at the Canadian Association of Nuclear Medicine 2018 Annual Meeting, March 22-25, 2018, Vancouver, BC, Canada.

A Monte Carlo study of Sn-117m radiosynoviorthesis to treat arthritic joints.
Gupta AC, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting, June 23-27, 2018, in Philadelphia, PA.

Simulation of Sn-117m radiosynoviorthesis including phagocytotic migration within the joint.
Wendt RE, et al. Abstract accepted at the 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Radiosynoviorthesis: Radioisotope therapy for arthritic conditions.
Liepe K, et al. Abstract accepted at the 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Global experience with radioisotopes used for RSO.
Liepe K. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting, June 14, 2017, Denver, CO.

Characteristics and comparison of RSO isotopes including Sn-117m.
Stevenson NR. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting, June 14, 2017, Denver, CO.

A comparison of tissue doses from colloidal Sn-117m, Re-186, Y-90 and Er-169 for radiosynoviorthesis using Monte Carlo simulation.
Wendt RE, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting, June 12, 2017, Denver, CO.

Improving radiosynoviorthesis using a Sn-117m colloid. (Scroll halfway down page)
Liepe K, et al. International Conference on Radiopharmaceutical Therapy 2016 Annual Meeting, November 13-17, 2016, Kerala, India. World J Nucl Med. 2016;15(Suppl 1):S3-S39.

117mSn colloid as a potential candidate to replace 169Er colloids in radiosynovectomy of small joints.
Liepe K, et al. European Association of Nuclear Medicine 2016 Annual Meeting, October 2016, Barcelona, Spain.

A comparison of Er-169 and Sn-117m radiation synoviorthesis using Monte Carlo simulation.
Wendt RE, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2016 Meeting, June 14, 2016, San Diego, CA.

Radiosynoviorthesis: A new therapeutic and diagnostic tool for canine joint inflammation.
Stevenson NR, et al. World Council on Isotopes Newsletter, 2016;5(3).

A novel Sn-117m colloid for radiosynovectomy.
Srivastava SC, et al. Society of Nuclear Medicine and Molecular Imaging 2015 Meeting, January 2015, San Antonio, TX.

A novel Sn-117m colloid for human radiosynoviorthesis clinical trials.
Stevenson NR, et al. Accepted for oral presentation at the 32nd Annual Congress of the European Association of Nuclear Medicine, October 11-16, 2016, Barcelona, Spain.

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Preclinical Studies

Sn-117m colloid distribution and autoradiography in the normal canine elbow.
Gonzales GR, et al. European Association of Nuclear Medicine 2016 Annual Meeting, October 2016, Barcelona, Spain.

A novel molecule for the systemic imaging and treatment of rheumatoid arthritis.
Stevenson NR, et al. E-poster presented at the European Association of Nuclear Medicine 2018 Annual Meeting, October 12-16, 2018, Dusseldorf, Germany.

Retention and radiation field of a Sn-117m colloidal suspension in canine intra-articular injections.
Stevenson NR, et al. Abstract accepted at the 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Preclinical trials using Sn-117m homogeneous colloid in radiosynoviorthesis.
Doerr CA. 12th International Conference on Radiopharmaceutical Therapy, October 19, 2017, Vienna, Austria.

Preclinical evaluation of tin-117m colloid as a radiosynoviorthesis agent for the treatment of canine elbow joint osteoarthrosis.
Lattimer JC, et al. American College of Veterinary Radiology, October 2016, Orlando FL.

Validation of the use of homogeneous Sn-117m colloid radiosynoviorthesis in a GLP osteoarthritis rat model.
Doerr CA, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2016 Meeting, June 14, 2016, San Diego, CA.

Homogeneous Sn-117m colloid radiosynovectomy results in rat models of joint disease.
Doerr CA, et al. Poster presented at the Society of Nuclear Medicine and Molecular Imaging 2015 Meeting, June 2015, Baltimore, MD.

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Synovetin OA™ Safety

Intra-articular injection of a tin-117m radiosynoviorthesis agent in normal canine elbows causes no adverse effects.
Lattimer JC, et al. Veterinary Radiology & Ultrasound. 2019;1-8.

Misadministration of Sn-117m colloid during radiosynoviorthesis presents no safety concerns.
Doerr CA, et al. Oral presentation to the Canadian Association of Nuclear Medicine 2019 Annual Meeting, February 7-10, 2019, Quebec City, Canada.

Canine Sn-117m colloid intra-articular injection release guidance.
Donecker JM, et al. Presented to the American College of Veterinary Radiology 2018 Annual Meeting, October 14-19, 2018, Fort Worth, TX.

Release of dogs following Sn-117m colloid intra-articular injections.
Wendt RE, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2018 Annual Meeting, June 23-27, 2018, Philadelphia, PA.

U.S. experience using new isotope Sn-117m homogeneous colloid for RSO in canines with OA.
Lattimer JC. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting, June 14, 2017, Denver, CO.

External radiation exposure following Sn-117m colloid intra-articular injections.
Wendt RE, et al. Poster presented at the Society of Nuclear Medicine and Molecular Imaging 2017 Meeting, June 13, 2017, Denver, CO.

Sn-117m colloid radiosynoviorthesis effects on canine OA synovitis as evaluated by PET, MRI, and behavioral measures. (Scroll halfway down page)
Doerr CA, et al. International Conference on Radiopharmaceutical Therapy 2016 Annual Meeting, November 13-17, 2016, Kerala, India. World J Nucl Med. 2016;15(Suppl 1):S3-S39.

Retention and biodistribution of Sn-117m colloid in intra-articular injections.
Lattimer JC, et al. Oral presentation at the Society of Nuclear Medicine and Molecular Imaging 2016 Meeting, June 14, 2016, San Diego, CA.

Evaluation of homogeneous Sn-117m colloid radiosynovectomy in normal dogs using scintigraphy, PET-MRI and other modalities.
Lattimer JC, et al. Poster presentation at the World Molecular Imaging 2015 Congress, September 3, 2015, Honolulu, HI.

Radiation Safety Considerations in the Treatment of Canine Skeletal Conditions using Sm-153, Y-90, Sn-117m.
Richard E.Wendt III, Kimberly A. Selting, Jimmy C. Lattimer, et al. Health Physics. March 9,2020;1-9. doi:10.1097/HP.0000000000001222

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Tin-117m, A Novel Conversion Electron

Novel treatments for arthritis in humans and animals using the theranostic isotope Sn-117m: Colloids and labeled molecules. Stevenson NR, et al. Poster presentation at the International Chemical 2015 Congress of Pacific Basin Societies, December 17, 2015, Honolulu, HI.

Production of Sn-117m in the BR2 high-flux reactor.
Ponsard B, et al. Poster presentation at the Theranostics 2019 World Congress, March 1-3, 2019, Jeju, Korea.

Applications of Sn-117m and the potential world supply and demand.
Stevenson NR. Presentation at KARA Radiation Promotion 2018 Conference, September 14, 2018, Busan, South Korea.

Manufacturing and applications of Sn-117m in nuclear medicine.
Stevenson NR. Invited lecture at the American Chemical Society Spring 2018 National Meeting, March 18-22, 2018, New Orleans, LA.

Sn-117m–A new isotope for treating arthritis.
Stevenson NR. Oral presentation to the International Isotope Society Symposium 2018 Meeting, June 3-7, 2018, Prague, Czech Republic.

Advances in the global use of isotopes for medicine, industry and environmental science.
Stevenson NR. Invited lecture at the American Physical Society Q2C Meeting, April 14-17, 2018, Columbus, OH.

Tin-117m: A new isotope and approach to radiosynoviorthesis and other therapies.
Stevenson NR. Invited lecture, 39th High Country Nuclear Medicine Conference, March 3-7, 2018, Sun Valley, ID.

Nuclear medicine applications of the novel theranostic isotope Sn-117m.
Gonzales GR, et al. Abstract accepted to the 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Novel treatments for arthritis in humans and animals using Sn-117m colloids and labeled molecules.
Stevenson NR. Abstract accepted at the 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Production and preparation of Sn-117m from the BR2 reactor.
Ponsard B, et al. 9th International Conference on Isotopes, November 12-16, 2017, Doha, Qatar.

Manufacturing and characteristics of Sn-117m based radiopharmaceuticals and medical devices.
Stevenson NR. 12th International Conference on Radiopharmaceutical Therapy, October 19, 2017, Vienna, Austria.

Nuclear medicine applications of Sn-117m.
Gonzales GR. 12th International Conference on Radiopharmaceutical Therapy, October 19, 2017, Vienna, Austria.

Preclinical evaluation of Sn-117m colloid as a radiosynoviorthesis agent for treatment of canine elbow joint osteoarthrosis.
Lattimer JC, et al. Oral presentation at the Veterinary Orthopedic Society 2017 Annual Meeting, March 13, 2017, Snowbird, UT.

My biz on isotopes: Serene, LLC.
Doerr CA. World Council on Isotopes, February 2017 Newsletter, pp 8-11.

Production and characteristics of a novel Sn-117m particulate suspension for application in human and veterinary radiosynoviorthesis. (Scroll halfway down page)
Stevenson NR, et al. International Conference on Radiopharmacuthical Therapy 2016 Annual Meeting, November 13-17, 2016, Kerala, India.

Manufacturing and nuclear medicine applications of the novel isotope Sn-117m.
Stevenson NR, et al. Invited oral presentation at the International Conference on Translational Research in Radio-Oncology | Physics for Health in Europe, February 15-19, 2016, Geneva, Switzerland.

Methods of producing high specific activity Sn-117m with commercial cyclotrons.
Stevenson NR, et al. Journal of Radioanalytical and Nuclear Chemistry. 2015;305(1):99-108.

Enabling simultaneous imaging and treatment with the theragnostic radionuclide Tin-117m.
Srivastava SC. TERACHEM 2014, September 2014, Italy.

Methods of producing high specific activity Sn-117m with commercial cyclotrons.
Stevenson NR. 8th International Conference on Isotopes, August 2014, Chicago, IL. Journal of Radioanalytical and Nuclear Chemistry. 2015;305(1):99-108.

Therapeutic radionuclides: Production, physical characteristics, and applications.
Srivastava SC, Mausner LF. In RP Baum (Ed.), Therapeutic Nuclear Medicine, Springer, 2014:12-46.

Production and applications of high specific activity Sn-117m-DOTA-Annexin.
Srivastava SC, et al. WIPR 2013: Latest Progress in the Field of RadioImmunoTherapy, July 2013, France.

Production and applications of high specific activity Sn-117m labeled compounds.
Stevenson NR. Radiometals 2013 Conference, June 2013, Sonoma Valley, CA.

Production and applications of very high specific activity Sn-117m.
Stevenson NR, et al. ACS, April 2013, New Orleans, LA.

Paving the way to personalized medicine: Production of some promising theragnostic radionuclides at Brookhaven National Laboratory.
Srivastava SC. Semin Nucl Med. 2012;42:151-163.

Production of Sn-117m in the BR2 high-flux reactor.
Ponsard B, et al. Applied Radiation and Isotopes. 2009;67:1158-1161.

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Synovetin OA™ delivers sustained OA pain relief.1

Synovetin OA™ provides targeted, non-systemic therapy.2

References:

  1. Data on file, Exubrion Therapeutics.
  2. Donecker JM, Fox SM. Safety and effectiveness of Synovetin OA™: Results of three randomized trials evaluating treatment of naturally occurring canine elbow osteoarthritis. Exubrion Therapeutics, July 2019.